Can psychedelics support women through perimenopause and menopause?

In this MenoMoment, Dr. Mindy Pelz shares emerging research around psilocybin, MDMA and the menopausal brain — and why this topic deserves a nuanced, science-led discussion.

In this conversation, we unpack:

·       The 5-HT2A serotonin receptor and its connection to estrogen and psilocybin 

·       Why serotonin shifts during perimenopause and menopause

·       Microdosing psilocybin and its potential effects on mood

·       The research behind MDMA-assisted therapy 

·       The default mode network and looping thoughts in midlife

·       Why therapeutic guidance and integration matter

Dr. Mindy shares her personal reflections on microdosing and therapeutic, MDMA-assisted therapy— and how these tools, when used legally and responsibly, may help some women interrupt self-critical patterns, improve emotional wellbeing and reconnect with their authentic voice during midlife.

This episode is not medical advice. It’s an exploration of neuroscience, emerging research and the evolving conversation around psychedelics and women’s health.

If you’re curious about the menopause brain, serotonin, mood changes, and alternative approaches to emotional wellbeing in midlife — this conversation will expand your perspective.

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FOLLOW for expert conversations on perimenopause, menopause, hormone health, brain health and midlife wellbeing.

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• Dr. Mindy Pelz
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