Marta Pecina MD PhD. is Assistant Professor of Psychiatry, Director of the Translational Neuroscience and Neuroimaging Lab of the Department of Psychiatry and the UPMC Western Psychiatric Hospital. This Podcast focuses on the Neurobiological basis of placebo effects. Placebos have great power. We explain how both expectation and conditioning generate strong placebo effects relevant to research and their therapeutic use. Ethical issues about placebo use are furthermore addressed.