Metastatic breast cancer treatment isn't one-size-fits-all. Providers must carefully balance clinical outcomes, toxicity, and patient lifestyle and preferences. Dr. Giancarlo Moscol joins Ms. Ashley Baker to outline a structured, three-tiered decision-making process that weighs treatment efficacy, side effect burden, and real-world logistics like administration route and patient support systems. Dr. Moscol is an Associate Professor in teh Department of Breast Medical Oncology at the University of Texas MD Anderson Cancer Center in Houston.