There is a broad range of possibilities when packaging Python with Nix.

The amount of Python formats alone can be overwhelming: requirements.txt, setup.py & pyproject.toml, not to mention Conda!

This talk aims to explain Python packaging with Nix, focusing on pyproject.nix & uv2nix, but I will also talk about other approaches and their trade-offs.

We'll start off with a short primer on the different Python packaging formats & methods while explaining a few of the things that make Python packaging particularly murky & difficult.

Then we'll go through a range of Nix packaging possibilities, starting with using plain nixpkgs & culminating in pyproject.nix & uv2nix.

Along the way the pros and cons of each will be explored and what approach to use when and where.

about this event: https://talks.nixcon.org/nixcon-2025/talk/Y8TSAW/