Isa's new fashion line is called Désine Celeste. Isa shares her inspiration for the line, which includes a desire for women to feel beautiful and to glorify God through fashion. The line incorporates elements such as pearls and crosses, and each collection has a purpose and meaning. The conversation highlights the importance of following God's calling and having faith in His plans. Isa encourages listeners to pursue their dreams and trust in God's timing and plan.