The Reframers dig into the complicated world of drugs. They trace the history of legal restrictions on various controlled substances, starting with an overview of prohibition in the 1920s and early 1930s and culminating with the current state of the “war on drugs” in the United States. They share their views on the effectiveness of prohibitions of controlled substances and discuss the consequences of these policies over time. The Reframers cover drug wars, police aggression, the opioid crisis, microdosing, and more in their discussion on this issue that has had wide-reaching impacts in our society.