Innovation policy is increasingly conceived as the shared responsibility of national and subnational governments, yet most countries are struggling with multilevel governance. During this presentation, José Guimón provides an overview of how different countries are dealing with regional innovation policy and of the institutions and tools used for national-regional coordination. Drawing on examples from Latin America, Eastern Europe and Asia, he will discuss policy implications for developing countries, which have decentralized their innovation policies more recently than developed countries, but face more acute challenges with respect to critical mass and institutional capacity.