In this episode of The 7-2-1, Dr. Kemi Olaiya and Dr. Cheryl Mensah continue the conversation on fertility preservation in sickle cell disease with Dr. Leslie Appiah, a leading expert in fertility preservation. Together, they break down what patients, families, and providers need to know, from insurance coverage and the hematologist’s role, to special considerations like hydration, anesthesia risks, and ovarian hyperstimulation syndrome. The discussion also explores how common sickle cell treatments such as hydroxyurea and iron chelation impact fertility preservation decisions. This episode offers practical insights for clinicians and families navigating complex choices around preserving fertility in the context of curative therapies.