In this episode of the Enforcement and Investigations Podcast Series, Christine Savage and Mark McPherson discuss recent research security enforcement actions involving the University of Florida and Cleveland Clinic, as well as the biotechnology company Sigma-Aldrich. The discussion offers insights and takeaways from these matters that research security and compliance professionals can use to enhance their institutions’ research security programs, and highlights the impact of cooperating with the DOJ’s National Security Division Voluntary Self-Disclosure Program.