During this episode of the Research talk, Helen Clare was joined by professor of physical chemistry and head of computational systems chemistry at the University of Southampton, Jeremy Frey. As well as his conducting his own experimental research he is; investigating how e-Science infrastructure helps make an intelligent laboratory; an enthusiastic supporter of interdisciplinary research, the PI of the EPSRC Network+ on artificial intelligence and automated scientific discovery. Together they discuss digital research infrastructure, how the current systems and tools need to change to better support research and the opportunities that could be realised with these advancements.