Diabetes Insights - Breakthroughs and Innovators

Results from the SOUL Trial: The Diabetologists' Perspective

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Watch the full interview on YouTube to learn more about the SOUL trial, a landmark study presented at the EASD 2025 Annual Meeting investigating cardiovascular outcomes with an oral GLP-1 receptor agonist.

In this episode, Dr Rodica Busui (Oregon Health & Science University-OHSU, Oregon, USA) explains why the SOUL trial represents a significant milestone in diabetes and cardiovascular care. She discusses how the oral formulation achieved a 14% reduction in major adverse cardiovascular events (MACE), matching results previously observed with injectable GLP-1 therapies.

Dr Busui also explores:

  • The relevance of the findings for people with type 2 diabetes at high cardiovascular risk
  • New insights into heart failure phenotypes, particularly HFpEF, and their growing prevalence
  • Why oral GLP-1 therapies may help expand access, especially for older adults or those unable to manage injections
  • Key safety observations regarding combined use with SGLT2 inhibitors, which was seen in nearly half of trial participants

    • Read the full publication for a deeper dive into the SOUL trial data once available online.

    Stay tuned for more expert insights and breakthrough conversations from EASD TV. To learn more about our expert speaker:

    • Dr Rodica Busui
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      Diabetes Insights - Breakthroughs and InnovatorsBy EASD - European Association for the Study of Diabetes