As part of our “Giants in Retina” series, Retina Rounds is honored to welcome Dr. Barry Kuppermann. For over 3 decades, Dr. Kuppermann has been an innovator and pioneer in the field of ophthalmic drug delivery, having made transformational contributions in the management of both infectious and inflammatory ocular disorders. In addition, Dr. Kuppermann has been an academic leader. As Chair of the Department of Ophthalmology at the University of California, Irvine and Director of the Gavin Herbert Eye Institute, Dr. Kuppermann has built one of the premier retina divisions and ophthalmology departments in the country. In this episode, Dr. Kuppermann talks about the guiding principles in his professional life, including intellectual curiosity and integrity, the role mentors and collaborators have played in his career arc, and the values that have kept him excited and engaged in academic medicine.