In the first episode, we welcome Lisa Harder and Yangfan Peng, who will give exciting insights into their research projects. Lisa Harder investigates cortico-striatal plasticity underlying phenotype manifestation in dystonia and discusses the potential applications of her findings, while Yangfan Peng will tell us about retuning pathway-specific neuronal population dynamics for movement initiation. Both will share their challenges, insights and the relevance of their work to the treatment of movement disorders in real life.