The first four seals in Revelation 6 speaks vividly of man’s attempt at replacing God through the use of totalitarian governments and the effects that has on human life. The antichrist will use his totalitarian regime to bring into effect all that we eventually see in Revelation 13 with the mark of the beast and a cashless society. When we see seal 5 opened, we then get a glimpse of the suffering that came as a result of this totalitarianism but God will judge all of that and bring His vengeance. The whole world will seek to escape it but they will be unable to hide from what God has in store for them.