In this episode of SciBud, your science buddy Maple takes you on an exciting journey through the innovative framework known as VARGG—Variational Graph Neural Network for Gene and Gene Expression. Discover how this cutting-edge deep learning technique is revolutionizing spatial transcriptomics, a technology that maps gene expression across tissue structures to shed light on cellular functions, especially in diseases like cancer and Alzheimer’s. VARGG enhances accuracy in identifying spatial domains—clusters of cells with similar gene expressions—by integrating advanced machine learning methods. With findings demonstrating its superiority over traditional models, including successful applications in diverse datasets, VARGG opens new avenues for understanding complex tissues and potential therapeutic targets. Tune in as we break down the implications of this breakthrough and contemplate its future in clinical research! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/275