Welcome back to Wired Healthcast. Today we’re talking about a new experimental obesity pill that may burn fat without ever touching your hunger. Unlike Ozempic and other GLP-1 drugs that curb your appetite, this compound works by activating a receptor called GPR75 in fat cells—and it actually revs up your metabolism. In a small Phase I trial, healthy men who received daily injections of the drug saw their resting energy expenditure jump by around 100 calories a day. They lost about 1.2 percent of their body weight over eight weeks, all while eating exactly the same diet. “These results suggest we can safely increase energy expenditure in humans,” says the lead researcher. No major side effects showed up, and now the team is gearing up for larger trials. If these findings hold, we could finally have an obesity treatment that burns calories rather than simply suppressing your appetite. That’s all for today’s episode—thanks for listening.
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