Welcome to Travere Therapeutics’ Rare Kidney Disease podcast, where rare kidney disease gets a spotlight. Host Chris Gisler brings together two leading voices in nephrology, Dr. Donald Kohan and Dr. Yelena Drexler, for an energetic conversation about why proteinuria matters so much in diseases like FSGS and IgA nephropathy.

What starts as a discussion of proteinuria as a lab value soon deepens: what is it, why does it mean more than just numbers, and how does it actually drive kidney injury? 

Dr. Donald Kohan breaks down the biology of endothelin, showing its role at every stage of glomerulonephritis. At the same time, Dr. Yelena Drexler links research to real patient care and shares the practical impact of proteinuria on outcomes.

Whether you’re a clinician, researcher, or patient advocate, this episode delivers clear takeaways—from the latest studies shaping proteinuria targets to the call for multi-pathway, biology-informed treatment strategies.

Speakers:

• Dr. Chris Gisler is a medical director at Travere Therapeutics and an adult Nephrologist
• Dr. Donald Kohan is a Professor of Medicine, Division of Nephrology & Hypertension at the University of Utah
• Dr. Yelena Drexler is an Associate Professor of Clinical Medicine, Division of Nephrology & Hypertension at the University of Miami 

Disclaimer: 

Guest speakers of the Rare Kidney Disease Show may be paid consultants of Travere Therapeutics. This podcast episode was recorded on March 6, 2026. Please always consult updated sources for the latest information, as information discussed may have changed since the recording date.