Shuai Ding et al., published a scientific review article in the International Journal of Molecular Science that explores the applications of the CRISPR/Cas9 gene editing system in cancer therapy. The review focuses on three primary applications: CRISPR-based CAR-T cell therapy, CRISPR screening techniques for identifying new drug targets and cancer-related genes, and the use of CRISPR for generating cancer models in vitro and in vivo. The authors discuss the CRISPR/Cas9 system's mechanism, its advantages over other gene editing technologies, and its potential benefits for cancer treatment. However, the review also acknowledges the challenges associated with CRISPR/Cas9 technology, including off-target effects, delivery issues, and the potential risk of carcinogenesis. The article highlights the ongoing research efforts to address these challenges and further refine this promising tool for combating cancer.