The Rotterdam Study is a long-term, population-based cohort study in the Netherlands focused on identifying risk factors and understanding the progression of multifactorial diseases, particularly in mid-life and older individuals. The research encompasses a broad range of disease areas including cardiovascular disease, diabetes, internal medicine, pulmonary disease, dermatology, neurological diseases, mental health, musculoskeletal diseases, otolaryngology, liver disease, population imaging, and population genomics. Researchers at the Rotterdam Study utilise various data collection methods including questionnaires, physical examinations, biological samples, and automated linkage to health records. They are actively investigating the roles of genetics, lifestyle, and environmental factors on disease development and progression.