Dr. Ruslan Medzhitov provides an overview of the field of inflammation and outlines its role in pathology and homeostasis. Medzhitov explains how Inflammation is generated when pathogens, allergens, or other perturbations are recognized by sensor cells that then release inflammatory mediators (cytokines and chemokines) to activate effector cells. Inflammation is then followed by a resolution phase that brings the system back to homeostasis.