RxUnedited

Sharing what we learned about euglycemic diabetic ketoacidosis topic through a brief case discussion. Thanks for listening!

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

A special collab with some friends on wellbeing. Hear the perspectives from other professionals outside of pharmacy. Thank you Thinh, Vince and Alan for helping to make this episode possible!

Meet our two wonderful guests Stephanie and Anh as they share and reflect on their search for a pharmacy residency. As always, thank you for listening!

We are back this time with an excite new article on early-rhythm control therapy in atrial fibrillation, the EAST-AFNET4 trial. Reference to the article is listed below.

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Kirchhof P, Camm AJ, Goette A, et al. Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med 2020;383:1305-16.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

This is one of my favorite episodes so far. Carolyn and Ann joined us to share their experience and perspectives on mental wellbeing and resilience. There has been a lot of effort in raising awareness for mental health recently, so instead of going over the same thing, let's hear what others have to say.

In this episode, we discuss the basics in identifying and treating acute cystitis and pyelonephritis.

References:

1. Kaye KS, Rice LB, Dane AL, et al. Fosfomycin for injection (ZTI-01) versus piperacillin-tazobactam for the treatment of complicated urinary tract infection including acute pyelonephritis: ZEUS, a phase 2/3 randomized trial. CID. 2019; 69: 2045-2056.

2. Cortes-Penfield NW, Trautner BW, Jump RLP. Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults. Infect Dis Clin North Am. 2017;31(4):673-688. doi:10.1016/j.idc.2017.07.002

3. Nicole LE, Gupta K, Bradley SF, et al. Clinical practice guidelines for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America. CID 2019;68(10):e83-75.

4. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. CID 2011;52(5):e103-120.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We review and discuss the clinical trials for both the Pfizer-BioNTech and Moderna COVID-19 vaccines.

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References:

1. Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [published online ahead of print, 2020 Dec 30]. N Engl J Med. 2020;NEJMoa2035389. doi:10.1056/NEJMoa2035389

2. Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

We present to you a bite-sized version of atrial fibrillation in this episode. Because we're pharmacists, we mainly focus on the medications used for atrial fibrillation :)

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References:

1. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: executive summary. J Am Coll Cardiol. 2014 Dec, 64 (21) 2246-2280.

2. January CT, Wann LS, Calkins H, et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons. Circulation. 2019;140:e125-e151.

3. Khan SU, Osman M, Khan MU, et al. Dual versus triple therapy for atrial fibrillation after percutaneous coronary intervention. Ann Intern Med. Doi:10.7326/M19-3763.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

In this episode, we discussed the principles of drug interactions and review some relevant drug interactions that we see commonly in practice.

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***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***

Welcome to our 10th episode! We answer your questions about cefepime-induced encephalopathy, serotonin syndrome, and others about pharmacy. Thank you all for your continued interest!

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Some references used for this episode:

Boyer EW, Shannon M. The Serotonin Syndrome. N Engl J Med 2005;352:1112-20.

Karkow DC, Kauer JF, Ernst EJ. Incidence of serotonin syndrome with combined use of linezolid and serotonin reuptake inhibitors compared with linezolid monotherapy. J Clin Psychopharmacol 2017 Oct;37(5):518-523.

Hassamal S, Miotto K, Dale W, et al. Tramadol: Understanding the risk of serotonin syndrome and seizures. Am J Med 2018;131:1382.e1-1382.e6.

Payne LE, Gagnon DJ, Riker RR, et al. Cefepime-induced neurotoxicity: a systematic review. Critical Care 2017;21:276.

Bhattacharyya S, Darby RR, Raibagkar P, et al. Antibiotic-associated encephalopathy. Neurology. 2016;86(10):963-971. doi:10.1212/WNL.0000000000002455.

***This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.***