Ever wonder why a patient’s SpO₂ can look great, but their tissues are still starving for oxygen? In this episode of ClinicalAdventurer, we break down the oxyhemoglobin dissociation curve — the key to understanding how oxygen is picked up in the lungs and released where it’s needed most. We’ll explore what causes that curve to shift left or right, how factors like pH, CO₂, and temperature play a role, and what these shifts mean for your clinical decision-making. If you’re ready to connect the dots between SpO₂, ABGs, and tissue oxygenation, this is the no-nonsense respiratory deep dive you need.