Dating back to 1860 in Poland, three sisters’ journeys with the BRCA mutation isn’t exactly the claim to fame they were hoping for.

Kathryn (Winn) Buckley, Bridget (Winn) Stillwell and Maureen (Winn) Boesen’s family was one of eight studied at Creighton University in the 1980s, and at one point, the most significant history of breast and ovarian cancer ever documented in the United States.

As they prepare for their book, titled “Nipples Optional,” to come out next year, the sisters sat down with CURE Talks Cancer to walk us through their family health history. They also discussed how the BRCA mutation has affected their lives and how they’ve talked about their family health history with their children.