An H II region or HII region is a region of interstellar atomic hydrogen that is ionized. It is typically a cloud in a molecular cloud of partially ionized gas in which star formation has recently taken place, with a size ranging from one to hundreds of light years, and density from a few to about a million particles per cubic cm. The Orion Nebula, now known to be an H II region, was observed in 1610 by Nicolas-Claude Fabri de Peiresc by telescope, the first such object discovered.

Source: https://en.wikipedia.org/wiki/H_II_region

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