Drs Madhukar Trivedi and Leanne M. Williams discuss defining subtypes and biotypes for depression to tailor more personalized treatments of major depressive disorder.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984466). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Depression https://emedicine.medscape.com/article/286759-overview

Defining Biotypes for Depression and Anxiety Based on Large-scale Circuit Dysfunction: A Theoretical Review of the Evidence and Future Directions for Clinical Translation https://pubmed.ncbi.nlm.nih.gov/27653321/

Depression From a Precision Mental Health Perspective: Utilizing Personalized Conceptualizations to Guide Personalized Treatments https://pubmed.ncbi.nlm.nih.gov/34045980/

Acute and Longer-term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report https://pubmed.ncbi.nlm.nih.gov/17074942/

Depression Is the Leading Cause of Disability Around the World https://pubmed.ncbi.nlm.nih.gov/28418490/

Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety https://pubmed.ncbi.nlm.nih.gov/34482948/

Precision Psychiatry: A Neural Circuit Taxonomy for Depression and Anxiety https://pubmed.ncbi.nlm.nih.gov/27150382/

Childhood Trauma Predicts Antidepressant Response in Adults With Major Depression: Data From the Randomized International Study to Predict Optimized Treatment for Depression https://pubmed.ncbi.nlm.nih.gov/27138798/

Effect of Antidepressant Treatment on Cognitive Impairments Associated With Depression: A Randomised Longitudinal Study https://pubmed.ncbi.nlm.nih.gov/26995298/

Neuromodulation Surgery for Psychiatric Disorders https://emedicine.medscape.com/article/1343677-overview#a10

Use of Transcranial Magnetic Stimulation for Depression https://pubmed.ncbi.nlm.nih.gov/31355095/

Understanding Emotions: Origins and Roles of the Amygdala https://pubmed.ncbi.nlm.nih.gov/34072960/

Digital Therapeutics for Mental Health: Is Attrition the Achilles Heel? https://pubmed.ncbi.nlm.nih.gov/35982936/