The Tuskegee Syphilis Experiment, conducted by the U.S. Public Health Service, casts a long shadow over the Black community when it comes to eroding trust in the healthcare system. Adding to this distrust are the obvious health inequities Black, Indigenous, and people of color experience, including disproportionate death rates from COVID-19. In this episode, we explore the role of public health in building back trust and improving health with these communities.