Welcome back to a new season of LSHTM Viral, where we will be taking a deep-dive into vaccines and speak to experts working real-time on COVID-19. LSHTM modeller Roz Eggo reacts to the UK’s roadmap announcement on 22 February for easing lockdown restrictions, explaining the science behind the government's decision and how vaccination will forge a way out of the pandemic. John Edmunds, a UK government science advisor and professor of infectious disease at LSHTM discussed how new, potentially dangerous variants of the virus can emerge and key considerations for vaccination at this scale.