Dr. Lucius Alistair once fancied himself a god among men. In his hands, the Forced Evolutionary Virus allowed him to reshape the human genome into his own twisted vision of perfection.

Before his experiments in Vault 76, before Lilith…Lucius left a secret legacy deep within the walls of the Eastern Regional Penitentiary. Long thought lost, Site C could contain a treasure trove of research and could be the key to unlocking FEV’s full potential.

Lilith and her team prepare to investigate the old prison, so she can claim her legacy…but the PACT is hot on their trail, eager to claim those secrets for themselves.

In an epic confrontation behind the old prison walls, Lilith will face off against her fiercest opponent even as Appalachia begins tearing itself about around them.

Far to the South, Trader Red and her band of survivors find themselves trapped by the Oni…a desperate message was sent to Vault Town and help is on the way, but will it arrive on time?

The final tales of Appalachia are being told…and the future is still uncertain.