The explosive COVID-19 outbreak in India has shone a striking light on one of the biggest moral issues of our time - vaccine equity. Subsequent halting of vaccine exports is severely affecting Africa and developing countries, and although 1.9 billion doses have been administered globally, many developing countries are yet to receive a single dose. In this episode we are joined by two global health leaders, Professor Peter Piot and Dr. Ayoade Alakija, who discuss vaccine nationalism, COVID-19 in Africa, and possible routes to improving health equity in the future.