In this episode, Jake leads us in a discussion of a manuscript entitled Once-Weekly Semaglutide in Adults with Overweight or Obesity (10.1056/NEJMoa2032183). This manuscript is the result of a massive international randomized clinical trial that enrolled 1961 people with overweight and obesity to examine the effect of once-weekly semaglutide on weight loss. These data have the potential to make a big change to how obesity and overweight are treated. Look out for our follow up episode where we look at a similar GLP1 receptor agonist (liraglutide) and the efficacy of adding exercise to the pharmacological treatment. 

TIME STAMPS

00:00:00 – 00:16:31                                        Intro/Catch up

00:16:31 – 00:19:31                                        Background

00:19:31 – 00:33:31                                        Description of Lifestyle Intervention

00:33:31 – 00:46:40                                        Trial Description/Methods

00:46:40 – 01:13:20                                        Data!!

01:13:20 – 01:25:06                                        Adverse Events

01:25:06 – 01:26:37                                        Semaglutide + Exercise?

01:26:37 – 01:33:08                                        Cost?

01:33:08 – 01:39:25                                        Muscle Mass Loss and How to Mitigate

01:39:25 – End                                                Wrap Up and Final Thoughts

 

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Edwin Miranda @EdwinRay91

Dr. Jake Mey @CakeNutrition

Dr. Austin Robinson @AusRob_PhD

Dr. Alec Chaves (Yes he is a PhD now) @AbcSience02