Today, we're tackling the absolutely mammoth topic of hyponatremia after JAMA recently published a fantastic article about its diagnosis and management.

Part 2's episode focuses on determining the cause of a patient's hypotonic hyponatremia. From here we also go on to discuss the pathophysiology of both the Syndrome of Inappropriate ADH secretion (or SIADH) and cerebral salt wasting before discussing the markedly different managements for these two conditions.

Lastly, we talk through the principles of managing hyponatremia.

Resources for today's episode:

Diagnosis and Management of Hyponatremia - A Review by Adrogue, H.J., Tucker, B.M. and Madras, N.E. (JAMA)

Hyponatremia StatPearls

Up to Date articles:

• Causes of hyponatremia without hypotonicity
• Causes of hypotonic hyponatremia in adults
• Diagnostic evaluation of adults with hyponatremia
• Overview of treatment of hyponatremia in adults
• Pathophysiology and aetiology of the syndrome of inappropriate antidiuretic hormone secretion (SIADH)
• Treatment of hyponatremia: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) and reset osmostat
• Cerebral salt wasting

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