Roger Pielke Jr. is a Professor at the University of Colorado Boulder, who studies the politics of science and authors a popular Substack blog called The Honest Broker. Never one to shy away from controversy, Prof. Pielke has done high-profile research and writing on climate change and natural disasters, the origins of COVID-19, and the inclusion of transgender and intersex women in women’s sports. We discuss the relationship between science and politics and what can go wrong when science is politicized.