In this SARCOMA CONNECT Guidelines Podcast, two SARCOMA CONNECT Experts, Prof. Robert Maki and Prof. Silvia Stacchiotti, discuss recent updates in the ESMO and NCCN bone sarcoma guidelines. Focussing on osteosarcoma and Ewing sarcoma, but also including chordoma and Giant Cell Tumour of bone, the Experts compare and contrast the latest updates to the guidelines. They highlight the key clinical practice learning points from the guidelines, discuss the latest clinical trial data, and consider what they mean for patients.