Sean P. Kane, PharmD, BCPS, speaks with Nadia Awad, PharmD, BCPS about Rumack-Matthew nomogram and acetaminophen toxicity. In the episode, the toxidrome of acetaminophen overdose is outlined and the nuances (including clinical practice pearls) are discussed regarding the nomogram used to decide whether N-acetylcysteine is warranted for acetaminophen toxicity.