Peter Simons covers a clinical trial that found lithium ineffective at preventing suicide attempts, an essay by Allen Frances on the overdiagnosis of depression and overprescription of antidepressants, a review of the ineffectiveness and dangers of antidepressants, and an analysis that revealed that esketamine failed five of its six clinical trials.

• Lithium No Better Than Placebo for Preventing Suicide Attempts
• New Review: Antidepressants Come with Minimal Benefits, Several Risks
• Allen Frances Takes on the Over-Prescription of Antidepressants
• Esketamine Failed in Five of its Six Efficacy Trials
• Ketamine Withdrawal Has Severe Consequences
• New Study of Ayahuasca Users Shows Placebo Effect in Action