Science with Spice - Between Experiments

Dr. Spice sits down with the project manager of the Canadian Biogenome Project - an ambitious, collaborative effort to try and sequence as many genomes as possible in Canada so there are reference genomes for the wider research community.

Together they discuss how the Canadian Biogenome Project decides which species to prioritize, how collaborators actually get samples and the process of actually building a reference genome - it's not easy!

How do scientists model kidney development in a dish?

On Science with Spice: Between Experiments, Dr. Spice sits down with Dr. Sara Qubisi, a pediatric kidney disease expert from SickKids Hospital

Learn how Dr. Qubisi isolates patient cells in a completely non-invasive approach to develop patient-specific induced pluripotent stem cell lines, how she uses these cell lines to make mini-kidneys in a dish and how vital kidneys are for human health.

Dr. Spice sits down with neurobiologist Dr. Pablo Andreas Munoz Llancao from Yale University School of Medicine.

In this conversation they talk about the cellular garbage truck - the lysosome, one of its regulator proteins - JIP3, and how both are vital in brain development!

Happy Pride Month!

Dr. Spice sits down with Dr. Angelico Obille (aka Kwaga Musselle) where they discuss their research into freshwater mussels to discover new proteins involved in making things sticky when it's wet - a potential new tool in medical adhesion!

Dr. Obille also shares their story about the challenges of becoming their true self as a scientist, drag queen and performer.

Checkout Dr. Obille's website: https://www.scientistanjo.com/

Checkout Dr. Obille's PNAS publication: https://www.pnas.org/doi/10.1073/pnas.2537453123?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

Checkout Science is a Drag: https://www.scienceisadrag.com/

Join us as we dive into the fascinating world of biochemistry with PhD candidate Carlo Armijo from Stanford University! In this episode, we explore U-F-M-ylation Cycling and Ribosome Recycling at the Endoplasmic Reticulum, and we discuss his groundbreaking research that is reshaping our understanding of bacterial defense mechanisms against viruses.

Key takeaways:

• Discover the role of UFMylation in protein translocation and its implications for neurodegenerative diseases like Alzheimer's.
• Learn how bacterial viruses, or bacteriophages, interact with their hosts and the unique immune responses bacteria have developed.
• Understand the significance of ribosome recycling and how it affects cellular health and function.

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Growing mini organs in a dish is the newest frontier in drug development, but it's a LOT more complex than simply growing cells... Join Dr. Spice as she discusses nanotechnology, bioscaffolds and brain organoids with the expert materials science engineer turned stem cell biologist and neuroscientist, Dr. Peter Serles, a post-doctoral fellow from Caltech and USC.