How Food Becomes Fuel: Liver Function, Digestion, ATP, and Free Radicals | Live Lecture Series
In this episode of Science with Susanna, we follow nutrients from digestion and absorption all the way to cellular energy production.
We begin with the liver’s major functions, including bile production, blood-glucose regulation, glycogen storage, ketone production, plasma-protein synthesis, cholesterol production, and the modification of medications. We also connect liver dysfunction with jaundice, fatty liver disease, cirrhosis, gallstones, and impaired blood clotting.
Next, we examine how the nervous system controls digestion, including the cranial nerves involved in chewing and swallowing, parasympathetic stimulation through the vagus nerve, and the independent activity of the enteric nervous system. We then trace the complete digestion and absorption of a hamburger, following carbohydrates, proteins, and fats from the mouth through the stomach, small intestine, portal circulation, lymphatic system, and liver.
Finally, we explore how cells turn nutrients into ATP. We compare aerobic and anaerobic respiration, explain hypoxia and ischemia, and connect limited oxygen delivery with lactate production and acidosis. The lecture concludes with free radicals, antioxidants, oxidative stress, and ischemia-reperfusion injury.
Practice questions are included throughout to help you apply the physiology and prepare for critical-thinking exam questions.
00:00 — Bile Production and Major Liver Functions
12:57 — Practice: Liver Functions
13:46 — Neural Control of Digestion
17:38 — Practice: Neural Control of Digestion
23:11 — Summary of Digestion
27:44 — Absorption of Nutrients
29:54 — Practice: Absorption of Nutrients
31:22 — Digestion of a Hamburger: Putting It All Together
43:21 — Aerobic Respiration: Making ATP Using Oxygen
53:28 — Anaerobic Respiration: Making ATP When Oxygen Is Limited
59:47 — Practice: Anaerobic Respiration
1:03:09 — Free Radicals, Antioxidants, and Oxidative Stress
1:07:03 — Practice: Free Radicals
Science with Susanna