Scientists are exploring how aging impacts COVID severity, focusing on lung aging and cellular senescence. As we age, our lungs lose efficiency in repair mechanisms, like basal cells and cilia, making us more vulnerable to infections.

Cellular senescence leads to zombie cells releasing inflammatory molecules, creating an inflammatory soup that affects healthy cells. This process, known as SASAP, worsens with SARS-CoV-2 infection, potentially explaining why COVID hits some harder than others.

By understanding these aging-related factors, researchers hope to develop new strategies like Senolytics to combat COVID and improve outcomes.

Study:

https://link.springer.com/article/10.1186/s13619-024-00201-1

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