We model external reality. Now, we model the reality inside a living cell. This is the ultimate sim-to-real: training a molecular machine in a simulation and compiling its blueprint into DNA. This is synthetic biology powered by biochemical World Models. We're not designing drugs; we're programming life.Current genetic engineering is hacking machine code with a magnet. A biochemical World Model is a full-stack simulator of the central dogma: DNA to RNA to protein to function.This moves us from hacking to programming. The prompt: 'Design a genetic circuit for a bacterium that detects the toxin melamine, glows blue, sequesters it, and self-destructs in 48 hours.'The model simulates millions of genetic designs in its latent space, evaluates for efficacy and side-effects, and outputs the optimal DNA sequence. You synthesize it. It works—because it was validated in a perfect digital twin of a cell first.This is the Biological API. The cell is hardware. The World Model is the compiler. DNA is the code. We move from reading the book of life to writing in it with precision.Applications rewrite civilization: bacteria that digest plastic, yeast that brew spider silk, immune cells reprogrammed to hunt a patient's specific cancer. This is programmable cellular agriculture.My controversial take is this: The first entity to deploy a general-purpose biochemical World Model will instantly become the most powerful entity on Earth. Its 'apps' are new life forms. Its 'updates' are pandemics or cures. The dual-use danger is absolute. The required containment isn't a lab coat; it's a global treaty with the gravity of the nuclear non-proliferation pact. We are not just modeling life. We are building the tool that makes us authors of life, and we are not ready for the burden.This has been The World Model Podcast. We don't just read the code of life—we prepare to become its editors under penalty of extinction. Subscribe now.