We had the pleasure of meeting with Lee Grant Irons and his daughter, Morgan Irons, during Season 5 of the Space 3D podcast. We’ve invited Lee Grant back this season to continue our discussion. This is part 3 and the conclusion of our latest interview.Lee Grant Irons is a scientist and engineer, with experience in the fields and industries of space plasma and computational physics, nuclear power design and operations, radioactive and hazardous waste management, environmental remediation, and large-scale engineering and construction projects.In this episode, cohosts Tom Hill and Eleanor O’Rangers continue learning about the key elements of Pancosmorio Theory put forth in Lee’s article recently published in Frontiers in Astronomy and Space Sciences entitled, Frontiers | Pancosmorio (world limit) theory of the sustainability of human migration and settlement in space (frontiersin.org).Briefly, Pancosmorio Theory draws on ecological thermodynamics theory and the methodology of abductive reasoning to consider the consequences of humans leaving Earth’s life-sustaining regenerative systems behind. The paper argues that human growth beyond Earth will be limited by the absence of these systems and the implications of leaving them behind.While the prospect of what lies ahead for humankind in establishing a permanent presence in space is daunting, Lee’s paper lays the groundwork for defining the prerequisite foundation for that bootstrapped settlement to flourish.