Delivering petabyte-scale computational resources to a large community of users while meeting stringent security and compliance requirements presents a host of technical challenges. Seven Bridges Genomics met and overcame them when building the Cancer Genomics Cloud Pilot (CGC) for the National Cancer Institute. The CGC helps users to solve massive computational problems involving multidimensional data, which include: running diverse analyses in a reproducible manner, collaborating with other researchers, and keeping personal data secure to comply with NIH regulations on controlled data sets. Seven Bridges will highlight the lessons learned along the way, as well as best practices for constructing secure and compliant platform services using Amazon S3, Amazon Glacier, AWS Identity and Access Management (IAM), Amazon VPC, and Amazon Route 53.