Supply chain fragility and geopolitical instability discussed as background to in-shoring pharmaceutical manufacturing by Dr. Fernando Muzzio, distinguished professor of chemical and biochemical engineering, Rutgers University and Frederic Kahn, VP Sales, Wavelength Pharmaceuticals. This discussion covers reforming regulations and economics, while introducing novel flow chemistries, robotics, digitalization, and a heightened agility for investment in education, national strategy and communications.