•Future insulin may be sensitive to blood sugar levels

Vidcast:  https://www.instagram.com/p/C8p83oENKLZ/

The insulin of today must be injected in accordance with a diabetic person’s current and expected blood sugar levels.  The insulin molecules of the future may regulate themselves according to the amounts of sugar in the blood surrounding them permitting the injection of a constant amount of drug or supplying it using an implantable depot.  Chinese research pharmacologists have developed a “smart” glucose-responsive insulin or GRI that does just that.  Insulin is complexed with an inactivating polymer that releases it in the presence of glucose.  This insulin-of-the-future tested successfully in mice and small pigs.  Much work must still be done, but the this self-regulating insulin will make life easier for diabetics…..someday soon.

https://www.nature.com/articles/s41551-023-01138-7

https://www.nejm.org/doi/full/10.1056/NEJMcibr2400047

#insulin #glucoseresponsive #selfregulating