Welcome to Cardiology Today – Recorded November 26, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac arrhythmias and incretin therapies. Key takeaway: Semaglutide Efficacy in H. F. pEF Across Age.

Article Links:

Article 1: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. (European journal of heart failure)

Article 2: Predictive factors for permanent pacemaker implantation and mortality after transcatheter aortic valve replacement in patients with pre-existing atrial fibrillation. (Cardiology)

Article 3: Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. (European journal of heart failure)

Article 4: Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension. (European heart journal. Cardiovascular Imaging)

Article 5: Value of cardiovascular magnetic resonance-derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion. (European heart journal. Cardiovascular Imaging)

Full episode page: https://podcast.explainheart.com/podcast/semaglutide-efficacy-in-h-f-pef-across-age-11-26-25/

Journal: European journal of heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41290376

Summary: Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups.

Journal: Cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41289183

Summary: Atrial fibrillation is the most common arrhythmia observed in patients undergoing transcatheter aortic valve replacement. This study provided specific data to identify predictors for permanent pacemaker implantation in patients with pre-existing atrial fibrillation. It also investigated the association between permanent pacemaker implantation and long-term mortality in this patient group, addressing a critical knowledge gap in transcatheter aortic valve replacement outcomes.

Journal: European journal of heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41290376

Summary: Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups.

Journal: European heart journal. Cardiovascular Imaging

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40972539

Summary: Novel echocardiographic indices of right ventricular myocardial work are valuable for evaluating pulmonary arterial hypertension. This study demonstrated that these right ventricular myocardial work indices predict haemodynamics and risk profile in patients with pulmonary arterial hypertension. The indices specifically identified patients at high risk for mortality and those with a worse haemodynamic profile, as confirmed by right heart catheterization.

Journal: European heart journal. Cardiovascular Imaging

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40916342

Summary: Visual assessment has traditionally been the primary method for detecting obstructive coronary artery disease using stress perfusion cardiovascular magnetic resonance. This study investigated the diagnostic performance of fully automated quantitative myocardial blood flow assessment in patients with coronary chronic total occlusion. The research provided valuable data on cardiovascular magnetic resonance derived quantitative myocardial blood flow, addressing a knowledge gap in the evaluation of chronic coronary occlusions.

Today’s date is November 26, 2025. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups.

Article number two. Predictive factors for permanent pacemaker implantation and mortality after transcatheter aortic valve replacement in patients with pre-existing atrial fibrillation. Atrial fibrillation is the most common arrhythmia observed in patients undergoing transcatheter aortic valve replacement. This study provided specific data to identify predictors for permanent pacemaker implantation in patients with pre-existing atrial fibrillation. It also investigated the association between permanent pacemaker implantation and long-term mortality in this patient group, addressing a critical knowledge gap in transcatheter aortic valve replacement outcomes.

Article number three. Effects of semaglutide in obesity-related heart failure with preserved ejection fraction across the age spectrum: Findings from the STEP-HFpEF programme. Semaglutide demonstrated efficacy in treating obesity-related Heart Failure with Preserved Ejection Fraction in the overall S. T. E. P. minus H. F. pEF trials. This pre-specified pooled subanalysis of the S. T. E. P. minus H. F. pEF program evaluated semaglutide’s effects across the age spectrum. The analysis provided important data addressing prior speculation that older patients might benefit less from incretin therapies, contributing to understanding its therapeutic application in diverse age groups.

Article number four. Echocardiographic right-ventricular global wasted work predicts haemodynamics and risk profile in pulmonary arterial hypertension. Novel echocardiographic indices of right ventricular myocardial work are valuable for evaluating pulmonary arterial hypertension. This study demonstrated that these right ventricular myocardial work indices predict haemodynamics and risk profile in patients with pulmonary arterial hypertension. The indices specifically identified patients at high risk for mortality and those with a worse haemodynamic profile, as confirmed by right heart catheterization.

Article number five. Value of cardiovascular magnetic resonance-derived quantitative myocardial blood flow assessment in the setting of chronic coronary occlusion. Visual assessment has traditionally been the primary method for detecting obstructive coronary artery disease using stress perfusion cardiovascular magnetic resonance. This study investigated the diagnostic performance of fully automated quantitative myocardial blood flow assessment in patients with coronary chronic total occlusion. The research provided valuable data on cardiovascular magnetic resonance derived quantitative myocardial blood flow, addressing a knowledge gap in the evaluation of chronic coronary occlusions.

Thank you for listening. Don’t forget to subscribe.

cardiac arrhythmias, incretin therapies, right ventricular myocardial work, pulmonary arterial hypertension, obesity, cardiovascular magnetic resonance, long-term mortality, diagnostic performance, coronary artery disease, coronary chronic total occlusion, S. T. E. P. minus H. F. pEF trials, haemodynamics, myocardial blood flow, permanent pacemaker implantation, semaglutide, transcatheter aortic valve replacement, echocardiography, right heart catheterization, Heart Failure with Preserved Ejection Fraction, atrial fibrillation.

Concise summaries of cardiovascular research for professionals.

Subscribe • Share • Follow

The post Semaglutide Efficacy in H. F. pEF Across Age 11/26/25 first appeared on Cardiology Today.