JACI: In Practice Associate Editor Scott Sicherer describes the September issue, the theme of which is “Microbiome and Clinical Allergy/Immunology.” Theme topics covered include the microbiome and prevention of allergic disease development, the environmental microbiome, the user of probiotics and prebiotics in allergy, and microbiome-immune interactions in allergy and asthma. Dr. Sicherer then presents the Highlights of the Original Articles in the issue, which are on the topics of anaphylaxis, asthma, dermatitis, eosinophilic disorders, food allergy, hypersensitivity pneumonitis, mast cell disorders, and rhinitis and sinusitis. Read the issue: https://bit.ly/JAIPSept2022. Access JACI: In Practice’s entire library: https://www.jaci-inpractice.org.