This release contains only the music track from Base by Base Episode 301.

Song title: Signal Maps
Original Base by Base episode: 301: Biobank Mendelian randomization prioritizes 6,447 genes and nominates ANXA2 for dyslipidemia
Original episode link: https://basebybase.com/episodes/biobank-mendelian-randomization-targets

Article metadata:
Article title: Leveraging large-scale biobanks for therapeutic target discovery
Journal: Human Genetics and Genomics Advances, 7 (2026) 100556. doi:10.1016/j.xhgg.2025.100556
DOI: 10.1016/j.xhgg.2025.100556
Reference: Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto ARV R, Matty R, Gaziano L, Liu Y, Smit IA, Zdrazil B, Tsepilov Y, Costa L, Kosik N, Huffman JE, Tartaglia GG, Bini G, Proietti G, Ioannidis H, Karim MA, Hunter F, Hemani G, Butterworth AS, Di Angelantonio E, Langenberg C, Ghoussaini M, Leach AR, Liao KP, Damrauer S, Selva LE, Whitbourne S, Tsao PS, Moser J, Gaunt T, Cai T, Whittaker JC, Million Veteran Program, Casas JP, Muralidhar S, Gaziano JM, Cho K, Pereira AC. Leveraging large-scale biobanks for therapeutic target discovery. Human Genetics and Genomics Advances. 7 (2026) 100556. https://doi.org/10.1016/j.xhgg.2025.100556.

Lyrics:
Verse 1
Late nights, bright screens, the pipeline hums
We stitch the traces where the molecules come
69,669 gene-trait links like constellations
Over two thousand phenotypes fold into our map

Pre-Chorus
Colocalization sharpens aim while it denies some light
Instruments argue, but patterns start to write
Our ranking climbs — precision-recall AUC 0.79

Chorus
Map the genes, light the way, turn the noise to signs
6,447 voices rising from the data lines
Nominate a target, ANXA2 for lipids in sight
We map the genes, we bring them into light

Verse 2
Blood signals whisper, pleiotropy blurs the trail
Harmonize the phenotypes, mend what might derail
Machine ranks the edges, a shortlist for the brave
Repurposing and new paths waiting to be paved

Bridge
A pipeline of discovery, charts that glow and swell
We balance specificity and sensitivity's spell
From network loops to a prioritized design
The future waits where signal meets the sign

Final Chorus
Map the genes, light the way, turn the noise to signs
6,447 names rising from the data lines
Precision climbing steady, reach the clearer height
We map the genes — and push the dark into light