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Signatures of neutral evolution in exponentially growing tumors: a theoretical perspective
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.07.29.227454v1?rss=1
Authors: Tung, H.-R., Durrett, R.
Abstract:
We investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are {lambda}_0<{lambda}_1 then the site frequency spectrum is c/f^ where ={lambda}_0/{lambda}_1. This is due to the advantageous mutations that produce the founders of the type 1 population. Mutations within the growing type 0 and type 1 populations follow the 1/f law. Our results show that neutral evolution can be distinguished from the two-type model using the site frequency spectrum.
Copy rights belong to original authors. Visit the link for more info
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Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2020.07.29.227454v1?rss=1
Authors: Tung, H.-R., Durrett, R.
Abstract:
We investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are {lambda}_0<{lambda}_1 then the site frequency spectrum is c/f^ where ={lambda}_0/{lambda}_1. This is due to the advantageous mutations that produce the founders of the type 1 population. Mutations within the growing type 0 and type 1 populations follow the 1/f law. Our results show that neutral evolution can be distinguished from the two-type model using the site frequency spectrum.
Copy rights belong to original authors. Visit the link for more info