Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD, highlight JACC Simultaneous Publications from the AHA 2025 Scientific Sessions, featuring three impactful clinical trials: (1) Effect of Aficamten vs. Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy, (2) Sacubitril/Valsartan vs. Enalapril in Heart Failure Due to Chagas Disease (ANSWER-HF Trial), and (3) Behavioral Economics and Medication Adherence for Hypertension. These SimPub studies showcase the spectrum of innovation—from precision therapy and global heart failure management to behavioral science—defining the next chapter of cardiovascular medicine.