In this episode of the HemaSphere podcast, host Charles De Bock engages with HemaSphere Editor in Chief Professor Jan Cools, Professor Heidi Segers, and Doctor Margo Aertgeerts to discuss their recent study on acute lymphoblastic leukemia (ALL). They explore the advancements in treatment, particularly for high-hyperdiploid ALL, the challenges of relapse, and the innovative use of single cell sequencing to uncover insights into genetic mutations and clonal composition. The conversation delves into the implications of RAS mutations, the technical challenges of analyzing rare cell populations, and the future of integrating transcriptomics with single cell analysis to enhance understanding and treatment of leukemia.

“Single‐cell DNA and surface protein”, is on our website, all major podcast platforms (Spotify, Apple Podcast, and more) and YouTube. Listen and enjoy casual, insightful discussions about #hematology research.

You can find the referenced article, in full and open access, here on the HemaSphere website.