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Protein biomarkers are proteins measured as indicators of biological processes. People often hope biomarkers will take the form of elevated or decreased amounts of single proteins, but few single protein measurements provide specific and sensitive indications of biological processes. In this episode of Translating Proteomics, Parag and Andreas discuss why it is difficult to find new biomarkers and describe how new techniques can enable the development of multi-protein, multi-time point, and even multiomic biomarkers that have more potential than any single protein measurement.

Some key points of discussion:

• Biomarkers are difficult to find because of the methods we use to find them and because there is a ton of variability in natural biological systems
• Most proteins are biomarkers
• We need more proteome-scale data over space and time to find new biomarkers

Learn more about biomarkers.

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